Men's health over 40

Health after 40 for men: testosterone, ApoB and metabolic health

For men over 40, three areas deserve a proper look: testosterone, ApoB as a measure of cardiovascular risk, and markers of metabolic health. Dr George Collins is a GMC-registered performance and longevity doctor who reviews all three together at Prosper, because a single number rarely means much without your history, symptoms and other results.

Testosterone: what it is and what a test can show

Testosterone is the main male sex hormone. It plays a part in energy, mood, libido, muscle, bone and recovery, and levels can change with age.

A blood test usually measures total testosterone, often alongside SHBG (a protein that binds it) and sometimes free testosterone, LH and FSH. Timing matters. Levels vary through the day and from one day to the next, so samples are normally taken in the morning and a single result is rarely the whole story.

Laboratories publish reference ranges, but where a number sits within one needs reading alongside symptoms, sleep, weight, alcohol, illness and medicines, all of which can influence a result. Dr George does not treat any single level as a target. If a result falls outside the laboratory range, GP review is advised. Any discussion of treatment requires a separate formal consultation.

ApoB: the cardiovascular marker worth understanding

ApoB is a protein found on the particles that carry cholesterol around the blood. Each of those particles carries one ApoB molecule, so the test counts particles rather than measuring how much cholesterol they hold.

Standard LDL cholesterol measures the cholesterol content instead. The two usually move together but can differ, which is why some doctors like to see both. An ApoB test is available in the UK through private laboratories, but it is not part of every standard cholesterol panel. Which markers go into your panel is decided by Dr George for your own context.

It is one piece of cardiovascular risk. Family history, blood pressure, smoking history and other results all sit alongside it.

Metabolic health: glucose, triglycerides and liver markers

Metabolic health describes how well your body handles energy. Doctors look at HbA1c (a measure of average blood sugar over recent months), fasting glucose, triglycerides, liver enzymes and sometimes fasting insulin, alongside waist measurement and body composition.

These markers rarely give a verdict on their own. Their value is in the pattern and in how they change over time, which is why repeat testing is part of the plan.

Why a doctor reading them together matters

Each of these results sits in relation to the others. Weight, sleep and metabolic health can all bear on hormone levels, and cardiovascular markers mean more once you know your blood pressure and family history. A doctor reading them together can decide what matters, what to repeat and what needs GP review.

At Prosper this happens inside Prosper Clarity, with a 60-minute consultation, a written report and a personalised action plan. The steps are on the how it works page, and Prosper works alongside NHS care.

On why the reading matters more than the report, see Blood test results reviewed by a doctor, not an app. Dr George's background is on the about page.

Questions people ask

Should every man over 40 have his testosterone tested?

Not automatically. Testing makes most sense when there are symptoms or a clinical reason, and a doctor can help you decide. Dr George would rather test for a reason than test for the sake of it.

What is a normal testosterone level?

Laboratories publish reference ranges, and they vary between laboratories. Dr George looks at where you sit within the range alongside your symptoms and other results, rather than treating one number as a target.

Is ApoB better than LDL cholesterol?

They measure different things. ApoB counts the particles that carry cholesterol, while LDL cholesterol measures the cholesterol those particles contain. Dr George reads them side by side.

Can Prosper prescribe testosterone?

Any discussion of prescribing requires a separate formal consultation, and it is not part of a blood test review. Dr George will tell you plainly whether treatment is something to explore or whether GP review is the better route.

What does it cost?

Prosper is a private, self-funded service. The recommended pathway and all expected costs are explained clearly on your discovery call.

Begin with a conversation

Book a complimentary discovery call

A short, no-obligation 15-minute video call with Dr George to talk through what you are looking for and whether Prosper is the right fit. Prosper is a private, self-funded service. The recommended pathway and all expected costs are explained clearly on your discovery call.

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Training and professional affiliations

Education and professional training from leading UK institutions.

University of Bath
University of Nottingham
University of Birmingham
Faculty of Sport and Exercise Medicine UK
Apex Longevity Academy
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